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Classic Gene Trap Papers

Gossler, A., Joyner, A. L., Rossant, J., and Skarnes, W. C. (1989). Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244, 463-465. http://www.ncbi.nlm.nih.gov:80/entrez
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Friedrich, G., and Soriano, P. (1991). Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice. Genes & Dev. 5, 1513-1523. http://www.ncbi.nlm.nih.gov:80/entrez/
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Skarnes, W. C., Auerbach, B. A., and Joyner, A. L. (1992). A gene trap approach in mouse embryonic stem cells: the lacZ reporter is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes & Dev. 6, 903-918. http://www.ncbi.nlm.nih.gov:80/entrez
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von Melchner, H., DeGregori, J. V., Rayburn, H., Reddy, S., Friedel, C., and Ruley, H. E. (1992). Selective disruption of genes expressed in totipotent embryonal stem cells. Genes & Dev. 6, 919-927. http://www.ncbi.nlm.nih.gov:80/entrez
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Wurst, W., Rossant, J., Prideaux, V., Kownacka, M., Joyner, A. L., Hill, D. P., Guillemot, F., Gasca, S., Cado, D., Auerbach, A., and Ang, S.-L. (1995). A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice. Genetics 139, 889-899. http://www.ncbi.nlm.nih.gov:80/entrez
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Forrester, L., Nagy, A., Sam, M., Watt, A., Stevenson, L., Bernstein, A., Joyner, A. L., and Wurst, W. (1996). Induction gene trapping in ES cells: Identification of developmentally regulated genes that respond to retinoic acid. Proc. Natl. Acad. Sci. USA 93, 1677-1682. http://www.ncbi.nlm.nih.gov:80/entrez
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Expression Trapping

Scherer, C.A., Chen, J., Nachabeh, A., Hopkins, N., Ruley, H.E. (1996). Transcriptional specificity of the pluripotent embryonic stem cell. Cell Growth & Diff. 7,1393-1401. http://www.ncbi.nlm.nih.gov:80/entrez
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Stanford, W. L., Caruana, G., Vallis, K. A., Inamdar, M., Hidaka, M., Bautch, V. L., and Bernstein, A. (1998). Expression trapping: Identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells. Blood. 92, 4622-4631. http://www.ncbi.nlm.nih.gov:80/entrez
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Hidaka, M., Caruana, G., Stanford, W.L., Sam, M., Correll, P.H., and Bernstein, A. (2000) Hzf and Hhl, two novel megakaryocytic genes identified by hematopoietic-specific gene trapping. Mech. Dev. 90, 3-14. http://www.ncbi.nlm.nih.gov:80/entrez
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Gene Trap Vectors

Shigeoka, T., Kawaichi, M., Ishida, Y. (2005). Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells. Nucleic Acids Res. 33(2):e20. http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=548380

Cobellis, G., Nicolaus, G., Iovino, M., Romito, A., Marra, E., Barbarisi, M., Sardiello, M., Di Giorgio, F.P., Iovino, N., Zollo, M., Ballabio, A., and Cortese, R. (2005). Tagging genes with cassette-exchange sites. Nucleic Acids Res. 33(4):e44. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15741177

Skarnes, W.C., Moss, J.E., Hurtley, S.M., and Beddington, R.S. (1995). Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A 92, 6592-6596. http://www.ncbi.nlm.nih.gov:80/entrez
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Yoshida, M., Yagi, T., Furuta, Y., Takayanagi, K., Kominami, R., Takeda, N., Tokunaga, T., Chiba, J., Ikawa, Y., and Aizawa, S. (1995). A new strategy of gene trapping in ES cells using 3'RACE. Trans. Res. 4, 277-287. http://www.ncbi.nlm.nih.gov:80/entrez
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Hicks, G.G., Shi, E.G., Li, X.M., Li, C.H., Pawlak, M., and Ruley, H.E. (1997). Functional genomics in mice by tagged sequence mutagenesis. Nature Genet. 16, 338-344. http://www.ncbi.nlm.nih.gov:80/entrez
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Salminen, M., Meyer, B. I., and Gruss, P. (1998). Efficient Poly A trap approach allows the capture of genes specifically active in differentiated embryonic stem cells and in mouse embryos. Dev. Dyn. 212, 326-333. http://www.ncbi.nlm.nih.gov:80/entrez
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Zambrowicz, B. P., Freidrich, G. A., Buxton, E. C., Lilleberg, S. L., Person, C., and Sands, A. T. (1998). Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature 392, 608-611. http://www.ncbi.nlm.nih.gov:80/entrez
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Hardouin, N., and Nagy, A. (2000). Gene-trap-based target site for cre-mediated transgenic insertion. Genesis 26, 245-252. http://www.ncbi.nlm.nih.gov:80/entrez
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In Vitro Differentiation of ES Cells

Doetschman, T.C., Eistetter, H., Katz, M., Schmidt, W., and Kemler R. (1985). The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morph. 87, 27-45. http://www.ncbi.nlm.nih.gov:80/entrez
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Schmitt, R.M., Bruyns, E., and Snodgrass, H.R. (1991). Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression. Genes & Dev. 5, 728-740. http://www.ncbi.nlm.nih.gov:80/entrez
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Wang, R., Clark, R., and Bautch, V.L. (1992). Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development. Development 114, 303-316. http://www.ncbi.nlm.nih.gov:80/entrez
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Keller, G., Kennedy, M., Papayannopoulou, T., and Wiles, M.V. (1993). Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol. Cell. Biol. 13, 473-486. http://www.ncbi.nlm.nih.gov:80/entrez
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Nakano, T., Kodama, H., and Honjo, T. (1994). Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science 265, 1098-1101. http://www.ncbi.nlm.nih.gov:80/entrez
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Maltsev, V.A., Wobus, A.M., Rohwedel, J., Bader, M., and Hescheler, J. (1994). Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ Res, 75,233-44. http://www.ncbi.nlm.nih.gov:80/entrez
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Bautch, V.L., Stanford, W.L., Rapoport, R., Russell, S., Byrum, R.S., and Futch, T.A. (1996). Blood island formation in attached cultures of murine embryonic stem cells. Dev. Dyn. 205, 1-12. http://www.ncbi.nlm.nih.gov:80/entrez
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Choi, K., Kennedy, M., Kazarov, A., Papadimitriou, J.C., and Keller, G. (1998). A common precursor for hematopoietic and endothelial cells. Development 125, 725-732. http://www.ncbi.nlm.nih.gov:80/entrez
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R1 ES Cells

Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., and Roder, J.C. (1993). Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A. 90, 8424-8428. http://www.ncbi.nlm.nih.gov:80/entrez
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Learning & Memory

Gingrich, J. and RODER, J.C. (1998). Inducible gene expression in the nervous system of transgenic mice". Ann. Rev. Neuroscience 21:377-405.

Jia ZP, Agopyan N, Miu P, Xiong Z, Henderson J, Gerlai R, Taverna F, Velumian A, MacDonald J, Carlen P, Abramow-Newerly W. and RODER, J.C. (1996). Enhanced LTP in mice deficient in the AMPA receptor, GluR2. (1996). Neuron 17:945-956. Li, C., Tropak, M., Gerlai, R., Clapoff, S., Abramow-Newerley, W., Trapp, B., Peterson, A., and RODER, J.C. (1994) Myelination in the absence of MAG. Nature 369:747-750.

Lu, YM, Mansuy, I, Kandel, E and RODER, JC. (2000). Calcineurin-mediated LTD of GABAergic Inhibition Underlies the Increased Excitability of CA1 Neurons Associated with LTP. Neuron 26:197-205.

Lu, Y.M., RODER, J.C., Davidow, J. and Salter, M.W. (1998). Src activation mediates induction of long-term potentiation in hippocampus. Science 279:1363-1367.

Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. and RODER, J.C. (1993) Derivation of completely cell culture-derived mice from early passage embryonic stem cells. PNAS 90:8424-8428.