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Centre for Modeling Human Disease
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Current Research Projects

Bone Group

(Jane Aubin, leader; Janet Henderson; Marc Grynpas; Bill Cole; Bill Stanford; Wolfgang Vogel)

The primary interests of this group is the genetic controls of bone mineral density (BMD) and other determinants of bone mass. BMD is a commonly used surrogate for predicting fracture risk in humans and there are now considerable efforts to uncover genes associated with low or high BMD. Osteoporosis is a major systemic skeletal disease, with estimates of approximately 1.4 million Canadians suffering from this disease. The use of ENU to generate models of abnormal bone mass can be used to identify and characterize the pathways involved in these phenotypes. Not only will this lead to a greater understanding of the pathogenesis of osteoporosis but also to better diagnostic, preventative and therapeutic strategies.

Cardiovascular Group

(Lee Adamson, leader; Benoit Bruneau; Mansoor Husain; Peter Backx)

The primary interest of this group is to dissect out the genetic and biochemical basis for cardiomyopathies and arrhythmias. Heart disease such as these is a major cause of morbidity and premature mortality in Canada and worldwide. To address the crucial need to understand the underlying genetic causes we undertake non-invasive screens on ENU mutagenized mice to identify mouse models of abnormal cardiac function.

Hematopoiesis Group

(William Stanford, leader; Dwayne Barber; Bob Paulson; Kelly McNagny; Chen Wang; Myron Cybulsky; Mark Minden)

The primary interests of this group is to enhance current understanding of mammalian hematopoiesis, including the identity and behavior of hematopoietic stem cells, the generation of lymphocyte diversity, and identification and functional analysis of key hematopoietic regulators. It is well known that the genes controlling hematopoietic development also play fundamental roles in hematopoietic disease. Here, we use ENU mutagenesis along with pharmacological stressors as a means to identify key genes involved in the regulation of hematopoietic development, homeostasis, and function.

Neurobehaviour Group

(John Roder, leader; Steve Clapcote; Tatiana Lipina; Wanda Abramow-Newerly; FrancoTaverna; Gang Xie; Allison Bechard)

The primary interest of this group is in the mechanisms which govern learning and memory within the mammalian central nervous system. Specifically, we are examining the means by which NMDA, AMPA and metabotropic class glutamate receptors and kinases (src) as well as phosphoresces (calcineurin) may act to regulate the process of memory acquisition through molecular, behavioral and electrophysiologic studies. We are also measuring the integration of these different levels in the firing of place cells. Further, we are interested in developing new animal models of MS, ALS, and schizophrenia as well as looking at regulated systems of gene expression (Cre, Tet).

Access the "Interactive neurologic database" (Henderson's NeuroMouse) []

Mount Sinai Hospital