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Centre for Modeling Human Disease
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Frequently Asked Questions (FAQs)

ENU Mutagenesis & Physiology FAQs

Neurobehaviour FAQs

Gene Trap FAQs


ENU Mutagenesis & Physiology FAQs

How do I access the CMHD services?
You may also view details of our services on the TCP website. If you have any questions or would like to request a service please contact Ann Flenniken at


I have an idea for a new screen – who should I talk to?

Please contact Ann Flenniken at


Where can I get more information on your disease models?

More information on our mutants can be found in our Mouse Model Database.

Neurobehaviour FAQs

How soon can you test my mice?
Will I be able get my mice back once testing is complete?
How many mice should I send and how much will it cost?
What is the recommended age of mice for neurobehavioural testing?
What should I try and avoid if possible?
Will you analyze data for me?
What steps are taken in order to prevent environmental factors from affecting my results?


How soon can you test my mice?

In order to import mice to the TCP for testing, a TCP importation form must be filled out and submitted to Ann Flenniken () or Julia Mitchell, TCP's Import/Export Coordinator (). At your request we would be happy to provide you with this form and assist you in completing it. The TCP Import/Export Coordinator will then contact your Animal Facility and request the health report to be sure the animals are suitable for importation to TCP. This process generally takes 2 weeks. Upon arrival, the mice are allowed to acclimatize for 1 week prior to testing.


Will I be able get my mice back once testing is complete?

Yes, we can send mice back as soon as we receive an importation approval from your facility.


How many mice should I send and how much will it cost?

We recommend a minimum of 5 mice from the affected group and 5 mice from the control group (littermates preferred) for a pilot study, and at least 2 or 3 times as many mice for any in-depth analysis. Mice should be of same sex and age.


What is the recommended age of mice for neurobehavioural testing?

Ideal age for neurobehavioural tests is 8 to 16 weeks. Mice that are less than 6 months of age should be fine for testing too.


What should I try and avoid if possible?

Mice are social animals and therefore, housing animals individually should be avoided as much as possible. Anxiety and stress levels in these animals tend to be higher than normal and they might affect the results at the end.


Will you analyze data for me?

We will send you raw data in excel or report format. Calculating mean values and standard deviations is available upon request only. Expert data interpretation is also available at additional cost. Please contact us for further details.


What steps are taken in order to prevent environmental factors from affecting my results?

We take great care of our animals as well as of the quality assurance and control during our testing. These are just few examples of what we do:

  • Always perform experiments at approximately the same time of day
  • Try to avoid testing animals on the day when cages are being changed
  • Allow mice to acclimatize to room’s conditions prior to testing
  • Same person always handles the mice

  • Noise levels, light intensity, and temperature are constantly monitored

 

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